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TO THE EDITOR: Erythrophagocytosis by monocytes or macrophages is occasionally seen in hematologic malignancy, autoimmune hemolytic anemia, and hemophagocytic lymphohistiocytosis [12]. However, erythrophagocytosis by neutrophils on the peripheral blood smear is an unusual morphological phenomenon. Erythrophagocytosis by neutrophils has been reported in patients with some hemolytic anemias, particularly paroxysmal cold hemoglobinuria (PCH), and other conditions including poisoning with potassium chlorate, sickle cell disease, and incompatible transfusion [3456]. Cases of erythrophagocytosis by neutrophils have rarely been observed in cold agglutinin disease (CAD) [789]. We report a female patient with CAD and the presence of erythrophagocytosis by neutrophils on the peripheral blood smear.
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